Abstract
A 74-year old woman with Ph1-negative chronic myelogenous leukemia (CML) and heterozygous for glucose-6-phosphate dehydrogenase (G6PD) was studied. Both A and B types of G6PD were found in skin. In contrast, white blood cells and platelets showed only a single G6PD type A. These results provide further evidence that Ph1-negative CML has a stem cell origin and develops clonally.
Publication types
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Case Reports
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Aged
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Blood Platelets / enzymology
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Chromosomes, Human, 21-22 and Y*
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Clone Cells / enzymology
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Erythrocytes / enzymology
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Female
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Glucosephosphate Dehydrogenase / metabolism
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Hematopoietic Stem Cells / enzymology*
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Humans
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Leukemia, Myeloid / enzymology
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Leukemia, Myeloid / genetics*
Substances
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Glucosephosphate Dehydrogenase