Calculation of recurrence risk in the case of ankylosing spondylitis taking into consideration the antigen HLA-B-27

Ann Hum Genet. 1984 Jan;48(1):79-86. doi: 10.1111/j.1469-1809.1984.tb00837.x.

Abstract

The authors have provided a new recurrence risk table of ankylosing spondylitis. The mathematical problem solved was to combine a continuous distribution for polygenic inheritance with a discrete one, HLA-B-27 antigen 'yes' or 'no'. Previously the highest probability of recurrence was 0.0785 in the case of an affected mother's son and it increased to 0.1416 when the B-27 antigen positive affected mother had a B-27 positive son.

MeSH terms

  • Adolescent
  • Female
  • HLA Antigens* / analysis
  • HLA-B27 Antigen
  • Humans
  • Male
  • Models, Genetic*
  • Risk
  • Spondylitis, Ankylosing / genetics*
  • Spondylitis, Ankylosing / immunology

Substances

  • HLA Antigens
  • HLA-B27 Antigen