Strong association between an HLA-DR antigen and thyroid carcinoma

Tissue Antigens. 1982 Aug;20(2):155-8. doi: 10.1111/j.1399-0039.1982.tb00340.x.

Abstract

A group of 20 patients affected with thyroid carcinoma, all from Southern Italy, was typed for HLA-A, -B, -C and -DR antigens. Sixteen of them (80%) typed for DR1, while in the control group (120 unrelated healthy individuals from the same region) only 22 (18.3%) shared the same antigen (chi 2 = 32.96). The data indicate a highly significant association between the HLA-DR1 gene and the thyroid carcinoma.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / epidemiology
  • Adenocarcinoma / genetics
  • Adenocarcinoma / immunology
  • Carcinoma, Papillary / epidemiology
  • Carcinoma, Papillary / genetics
  • Carcinoma, Papillary / immunology
  • Female
  • Genes, MHC Class II*
  • HLA Antigens / genetics
  • HLA-B Antigens
  • HLA-C Antigens
  • HLA-DR Antigens
  • Histocompatibility Antigens Class II / immunology
  • Histocompatibility Testing
  • Humans
  • Italy
  • Male
  • Thyroid Neoplasms / epidemiology
  • Thyroid Neoplasms / genetics
  • Thyroid Neoplasms / immunology*

Substances

  • HLA Antigens
  • HLA-B Antigens
  • HLA-C Antigens
  • HLA-DR Antigens
  • Histocompatibility Antigens Class II