Abstract
A group of 20 patients affected with thyroid carcinoma, all from Southern Italy, was typed for HLA-A, -B, -C and -DR antigens. Sixteen of them (80%) typed for DR1, while in the control group (120 unrelated healthy individuals from the same region) only 22 (18.3%) shared the same antigen (chi 2 = 32.96). The data indicate a highly significant association between the HLA-DR1 gene and the thyroid carcinoma.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenocarcinoma / epidemiology
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Adenocarcinoma / genetics
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Adenocarcinoma / immunology
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Carcinoma, Papillary / epidemiology
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Carcinoma, Papillary / genetics
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Carcinoma, Papillary / immunology
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Female
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Genes, MHC Class II*
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HLA Antigens / genetics
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HLA-B Antigens
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HLA-C Antigens
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HLA-DR Antigens
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Histocompatibility Antigens Class II / immunology
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Histocompatibility Testing
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Humans
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Italy
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Male
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Thyroid Neoplasms / epidemiology
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Thyroid Neoplasms / genetics
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Thyroid Neoplasms / immunology*
Substances
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HLA Antigens
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HLA-B Antigens
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HLA-C Antigens
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HLA-DR Antigens
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Histocompatibility Antigens Class II