Abstract
We studied 5 patients with essential thrombocythemia utilizing glucose-6-phosphate dehydrogenase (G-6-PD) enzyme as a cell marker for determining clonality. One of the patients was found to be heterozygous for isoenzymes B and A in the nonhaemopoietic tissues such as fibroblasts, but manifested only isoenzyme type B in the erythrocytes, neutrophils, and platelets. Our studies support the concept that essential thrombocythemia is a clonal disorder arising in a multipotent stem cell.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Blood Platelets / enzymology
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Clone Cells / enzymology
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Clone Cells / pathology*
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Erythrocytes / enzymology
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Female
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Fibroblasts / enzymology
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Glucosephosphate Dehydrogenase / analysis
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Glucosephosphate Dehydrogenase / genetics
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Granulocytes / enzymology
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Heterozygote
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Homozygote
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Humans
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Isoenzymes / analysis
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Isoenzymes / genetics
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Middle Aged
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Thrombocytosis / enzymology
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Thrombocytosis / genetics*
Substances
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Isoenzymes
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Glucosephosphate Dehydrogenase