Anterior segment mesenchymal dysgenesis: probable linkage to the MNS blood group on chromosome 4

Am J Hum Genet. 1982 Mar;34(2):245-9.

Abstract

Thirty-seven blood samples were analyzed for linkage from members of a single family with an anterior segment mesenchymal dysgenesis (ASMD1) with variable expressivity affecting members of at least six generations. Maximum-likelihood analysis for linkage between ASMD1 and 14 biochemical and serological markers in the family showed a probable linkage between ASMD1 and the MNS blood group on the long arm of chromosome 4 (Z = 2.36 at a recombination fraction of .09).

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Chromosome Mapping*
  • Chromosomes, Human, 4-5*
  • Corneal Dystrophies, Hereditary / genetics*
  • Descemet Membrane / abnormalities
  • Female
  • Genes, Dominant
  • Genetic Linkage
  • Genetic Markers
  • Humans
  • MNSs Blood-Group System / genetics*
  • Male
  • Pedigree
  • Phenotype
  • Syndrome

Substances

  • Genetic Markers
  • MNSs Blood-Group System