C2 deficient systemic lupus erythematosus: its association with anti-Ro (SSA) antibodies

Arch Dermatol. 1982 Aug;118(8):584-7.

Abstract

C2 deficiency is the most common complement component deficiency. While individuals with C2 deficiency may be completely normal, a lupus erythematosus-like disease process has developed in some. A 28-year-old woman had a chronic photodermatitis, arthralgias, and mesangial lupus nephritis, She has C2 deficiency associated with an HLA-Dw2 transplantation antigen. Her serum has shown antibodies to the macromolecule Ro (the A antigen in Sjögren's syndrome), while failing to demonstrate antinuclear antibodies in routine laboratory determinations.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antigens / immunology*
  • Autoantibodies / analysis*
  • Autoantigens*
  • Complement C2 / deficiency*
  • Complement C2 / genetics
  • Female
  • HLA-DR2 Antigen
  • Histocompatibility Antigens Class II / genetics
  • Humans
  • Lupus Erythematosus, Systemic / genetics
  • Lupus Erythematosus, Systemic / immunology*
  • Lupus Erythematosus, Systemic / pathology
  • Male
  • RNA, Small Cytoplasmic*
  • Ribonucleoproteins*
  • Sjogren's Syndrome / immunology*

Substances

  • Antigens
  • Autoantibodies
  • Autoantigens
  • Complement C2
  • HLA-DR2 Antigen
  • Histocompatibility Antigens Class II
  • RNA, Small Cytoplasmic
  • RO60 protein, human
  • Ribonucleoproteins
  • SS-A antigen