Abstract
C2 deficiency is the most common complement component deficiency. While individuals with C2 deficiency may be completely normal, a lupus erythematosus-like disease process has developed in some. A 28-year-old woman had a chronic photodermatitis, arthralgias, and mesangial lupus nephritis, She has C2 deficiency associated with an HLA-Dw2 transplantation antigen. Her serum has shown antibodies to the macromolecule Ro (the A antigen in Sjögren's syndrome), while failing to demonstrate antinuclear antibodies in routine laboratory determinations.
MeSH terms
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Adult
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Antigens / immunology*
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Autoantibodies / analysis*
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Autoantigens*
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Complement C2 / deficiency*
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Complement C2 / genetics
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Female
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HLA-DR2 Antigen
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Histocompatibility Antigens Class II / genetics
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Humans
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Lupus Erythematosus, Systemic / genetics
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Lupus Erythematosus, Systemic / immunology*
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Lupus Erythematosus, Systemic / pathology
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Male
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RNA, Small Cytoplasmic*
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Ribonucleoproteins*
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Sjogren's Syndrome / immunology*
Substances
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Antigens
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Autoantibodies
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Autoantigens
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Complement C2
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HLA-DR2 Antigen
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Histocompatibility Antigens Class II
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RNA, Small Cytoplasmic
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RO60 protein, human
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Ribonucleoproteins
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SS-A antigen