Abstract
Data from English families confirms the probable linkage of the loci for autosomal dominant type I hereditary motor and sensory neuropathy (HMSN) and the Duffy blood group. The locus for autosomal dominant type I HMSN is in chromosome 1 near the centromere, about 15 centimorgans from the Duffy locus. The linkage between type I HMSN and the Duffy locus and the two recombinants found between Duffy and type II HMSN support the hypothesis that there are at least two genetic variants of autosomal dominant HMSN.
MeSH terms
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Adult
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Blood Group Antigens / genetics*
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Charcot-Marie-Tooth Disease / genetics
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Chromosome Aberrations / genetics
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Chromosome Disorders
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Chromosome Mapping
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Chromosomes, Human, 1-3
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Duffy Blood-Group System / genetics*
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Genes, Dominant*
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Genetic Linkage
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Genotype
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Humans
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Middle Aged
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Motor Neurons*
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Muscular Atrophy / genetics
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Nervous System Diseases / genetics
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Neural Conduction
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Neuromuscular Diseases / genetics*
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Pedigree
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Phenotype
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Sensation*
Substances
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Blood Group Antigens
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Duffy Blood-Group System