Duplication followed by deletion accounts for the structure of an Indian deletion beta (0)-thalassemia gene

Nucleic Acids Res. 1982 Dec 20;10(24):8025-9. doi: 10.1093/nar/10.24.8025.

Abstract

Nucleotide sequence analysis of a cloned deletion beta-globin gene from a patient with beta(0)-thalassemia demonstrates a 619 nucleotide deletion extending from the 3' third of the second intervening sequence through 209 bases of 3' flanking DNA. However, an additional novel heptanucleotide was identified between the deletion endpoints, suggesting a complex etiology for this rearrangement.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Base Sequence
  • Chromosome Deletion*
  • Cloning, Molecular*
  • Genes*
  • Globins / genetics*
  • Humans
  • Molecular Sequence Data
  • Oligodeoxyribonucleotides / analysis
  • Thalassemia / genetics*

Substances

  • Oligodeoxyribonucleotides
  • Globins

Associated data

  • GENBANK/J00093
  • GENBANK/J00094
  • GENBANK/J00096
  • GENBANK/J00158
  • GENBANK/J00159
  • GENBANK/J00160
  • GENBANK/J00161
  • GENBANK/J00162
  • GENBANK/J00163
  • GENBANK/J00164
  • GENBANK/J00165
  • GENBANK/J00166
  • GENBANK/J00167
  • GENBANK/J00168
  • GENBANK/J00169
  • GENBANK/J00170
  • GENBANK/J00171
  • GENBANK/J00172
  • GENBANK/J00173
  • GENBANK/J00174
  • GENBANK/J00175
  • GENBANK/J00177
  • GENBANK/J00178
  • GENBANK/J00179
  • GENBANK/K01239
  • GENBANK/K01890
  • GENBANK/K01898
  • GENBANK/K02544
  • GENBANK/M18047