Abstract
Apolipoprotein E4 has been confirmed as a genetic risk factor for Alzheimer's disease. Although several hypotheses have been advanced to explain how the inheritance of apolipoprotein E isoforms affects the rate of Alzheimer's disease expression, the mechanism whereby apolipoprotein E is involved in the pathogenesis of Alzheimer's disease is still uncertain. To clarify the way in which the apolipoprotein E4 isoform differs from the others, we generated a monoclonal antibody specifically reactive with the apolipoprotein E4 isoform. This antibody suggests that the polymorphic site is important in differentiating the ApoE4 isoform from others.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alzheimer Disease / epidemiology
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Alzheimer Disease / genetics
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Amino Acid Sequence
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Antibodies, Monoclonal*
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Antibody Specificity
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Apolipoprotein E4
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Apolipoproteins E / chemistry*
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Apolipoproteins E / genetics*
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Apolipoproteins E / immunology
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Baculoviridae
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Enzyme-Linked Immunosorbent Assay
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Humans
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Molecular Sequence Data
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Peptide Fragments / chemistry
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Peptide Fragments / immunology
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Polymorphism, Genetic*
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Recombinant Proteins / chemistry
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Recombinant Proteins / immunology
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Risk Factors
Substances
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Antibodies, Monoclonal
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Apolipoprotein E4
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Apolipoproteins E
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Peptide Fragments
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Recombinant Proteins