Abstract
In experimental B-cell infections, Epstein-Barr virus induced sustained expression of V(D)J recombinase-activating genes RAG1 and RAG2, whose aberrant activity has been implicated in chromosomal translocations in B-cell neoplasms. In cell lines in which RAG1 and RAG2 were detected, virus integrated into cellular DNA rather than assumed the configuration of extrachromosomal episomes. Expression of the Epstein-Barr virus nuclear antigen 1 in transient transfection assays was sufficient to induce both recombinase-activating genes.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antigens, Viral / metabolism
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Base Sequence
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Burkitt Lymphoma
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Cell Line
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DNA Nucleotidyltransferases / biosynthesis*
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DNA Primers
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DNA-Binding Proteins / metabolism
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Enzyme Activation
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Epstein-Barr Virus Nuclear Antigens
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Gene Expression Regulation, Enzymologic*
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Gene Expression Regulation, Viral*
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Herpesvirus 4, Human / genetics*
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Humans
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Molecular Sequence Data
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Polymerase Chain Reaction
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Restriction Mapping
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Trans-Activators / metabolism
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Tumor Cells, Cultured
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VDJ Recombinases
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Virus Integration
Substances
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Antigens, Viral
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DNA Primers
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DNA-Binding Proteins
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Epstein-Barr Virus Nuclear Antigens
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Trans-Activators
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DNA Nucleotidyltransferases
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VDJ Recombinases