Abstract
The search for tumour-specific markers is one of the chief goals in cancer biology. We show that the translocation t(12;16)(q13:p11) in malignant myxoid liposarcoma can be a fusion of the CHOP dominant negative transcription factor gene with a novel gene, FUS, which can result in fusion of the FUS glycine-rich protein with the whole CHOP coding region. The data support the concept that protein fusion may commonly occur in solid tumours resulting in tumour-specific markers of potential clinical importance. The data also indicate the importance of transcription disruption in the pathogenesis of solid tumours.
MeSH terms
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Amino Acid Sequence
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Base Sequence
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CCAAT-Enhancer-Binding Proteins*
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Chromosomes, Human, Pair 12 / ultrastructure*
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Chromosomes, Human, Pair 16 / ultrastructure*
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DNA / genetics
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DNA, Neoplasm / genetics
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DNA-Binding Proteins / genetics*
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Gene Expression Regulation, Neoplastic
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Genes, Dominant
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Heterogeneous-Nuclear Ribonucleoproteins
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Humans
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Liposarcoma / genetics*
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Molecular Sequence Data
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Neoplasm Proteins / genetics*
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Nuclear Proteins / genetics*
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Polymerase Chain Reaction
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RNA-Binding Protein FUS
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Ribonucleoproteins / genetics*
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Transcription Factor CHOP
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Transcription Factors / genetics*
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Transcription, Genetic
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Translocation, Genetic*
Substances
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CCAAT-Enhancer-Binding Proteins
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DDIT3 protein, human
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DNA, Neoplasm
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DNA-Binding Proteins
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Heterogeneous-Nuclear Ribonucleoproteins
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Neoplasm Proteins
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Nuclear Proteins
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RNA-Binding Protein FUS
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Ribonucleoproteins
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Transcription Factors
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Transcription Factor CHOP
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DNA
Associated data
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GENBANK/X71427
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GENBANK/X71428