Expression of CD44 in prostate cancer cells

Cancer Lett. 1994 Jan 15;76(1):63-9. doi: 10.1016/0304-3835(94)90135-x.

Abstract

Expression of CD44, the cellular hyaluronate receptor, was examined in human prostate cell lines. CD44 mRNA was detected in cell lines PC3 and DU145, both established from organ metastases of prostate adenocarcinoma, but not in cell line LNCaP, established from a lymph node metastasis. PC3 and DU145, but not LNCaP, are tumorigenic and metastatic in nude mice. Of the CD44 mRNA species identified, the standard CD44s as well as variant isoforms CD44v7, CD44v10, CD44v14, CD44v13-v14, CD44v12-v14 and CD44v7-v14 are represented.

Publication types

  • Comparative Study

MeSH terms

  • Adenocarcinoma / genetics*
  • Adenocarcinoma / pathology
  • Adenocarcinoma / secondary
  • Base Sequence
  • Bone Neoplasms / secondary
  • Carrier Proteins / genetics*
  • Cloning, Molecular
  • DNA, Neoplasm / genetics
  • Gene Expression / genetics
  • Genome, Human
  • Humans
  • Hyaluronan Receptors
  • Male
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • Prostatic Neoplasms / genetics*
  • Prostatic Neoplasms / pathology
  • Receptors, Cell Surface / genetics*
  • Receptors, Lymphocyte Homing / genetics*
  • Tumor Cells, Cultured

Substances

  • Carrier Proteins
  • DNA, Neoplasm
  • Hyaluronan Receptors
  • Receptors, Cell Surface
  • Receptors, Lymphocyte Homing