Abstract
The mechanisms of extramedullary leukemic infiltration are not well characterized. The cell-surface glycoprotein CD56, which is identical to the neural cell adhesion molecule, may be involved. Using the Leu-19 antibody and flow cytometric methods, the leukemic blasts of 22% (70 of 314) of patients were CD56 positive. This was most common in acute monocytic leukemia (15 of 18, 83%) and in patients with the cytogenetic abnormalities t(8;21) (seven of 13, 54%) and trisomy 8 (nine of 22, 41%). CD56 expression was not associated with extramedullary leukemic infiltration, but was correlated with positivity for CD11b (p < 0.001), CD14 (p < 0.001) and CD19 (p = 0.018). Although associated with morphologic and cytogenetic features, CD56 expression alone cannot account for most instances of tissue infiltration in acute myeloid leukemia (AML).
MeSH terms
-
Adolescent
-
Adult
-
Aged
-
Aged, 80 and over
-
Animals
-
Antigens, CD / analysis*
-
Antigens, CD19
-
Antigens, Differentiation, B-Lymphocyte / analysis
-
Antigens, Differentiation, Myelomonocytic / analysis
-
Antigens, Differentiation, T-Lymphocyte / analysis*
-
CD56 Antigen
-
Cats
-
Cell Adhesion Molecules, Neuronal / analysis*
-
Chromosome Aberrations*
-
Chromosomes, Human, Pair 21
-
Chromosomes, Human, Pair 8
-
Female
-
Flow Cytometry
-
Humans
-
Immunophenotyping
-
Karyotyping
-
Leukemia, Monocytic, Acute / immunology
-
Leukemia, Myeloid, Acute / genetics
-
Leukemia, Myeloid, Acute / immunology*
-
Leukemia, Myeloid, Acute / pathology
-
Leukemic Infiltration
-
Lipopolysaccharide Receptors
-
Macrophage-1 Antigen / analysis
-
Male
-
Translocation, Genetic
-
Trisomy
Substances
-
Antigens, CD
-
Antigens, CD19
-
Antigens, Differentiation, B-Lymphocyte
-
Antigens, Differentiation, Myelomonocytic
-
Antigens, Differentiation, T-Lymphocyte
-
CD56 Antigen
-
Cell Adhesion Molecules, Neuronal
-
Lipopolysaccharide Receptors
-
Macrophage-1 Antigen