Abstract
We report here a rare case of biphenotypic M0 acute myeloid leukemia (AML) associated with trisomy 4. The literature of trisomy 4 in acute leukemia was reviewed. M2 and M4 AML are the most common FAB subtypes associated with trisomy 4. The clinical course of this entity is generally comparable with other non-trisomy 4 cases of AML. Despite the speculation made when first described, no specific environmental toxin has been found to be associated with this entity. C-kit oncogene has been mapped to chromosome 4 recently, and the role of this proto-oncogene in leukemogenesis of trisomy 4 associated leukemia should be further investigated.
MeSH terms
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Acute Disease
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Adult
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Antigens, CD / analysis
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Antigens, CD7
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Antigens, Differentiation, T-Lymphocyte / analysis
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Biomarkers, Tumor / analysis
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CD13 Antigens / analysis
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Chromosomes, Human, Pair 4*
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DNA Nucleotidylexotransferase / analysis
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Diagnosis, Differential
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Fatal Outcome
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Humans
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Leukemia, Myeloid / classification
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Leukemia, Myeloid / diagnosis
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Leukemia, Myeloid / genetics
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Leukemia, Myeloid / pathology*
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Male
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Neoplasm Proteins / analysis
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Phenotype
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis
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Proto-Oncogene Mas
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Proto-Oncogenes
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Trisomy*
Substances
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Antigens, CD
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Antigens, CD7
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Antigens, Differentiation, T-Lymphocyte
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Biomarkers, Tumor
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MAS1 protein, human
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Neoplasm Proteins
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Proto-Oncogene Mas
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DNA Nucleotidylexotransferase
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CD13 Antigens