Abstract
A case of acute monocytic leukemia with rearrangement of the immunoglobulin heavy-chain gene and strong cytoplasmic immunoglobulin expression in a young patient treated with multi-drug chemotherapy for primary seminomatous germ cell tumor 13 months earlier is reported. The short latency period from the beginning of therapy for primary germ cell tumor and the abrupt onset of leukemia with no identifiable prodrome bear similarities to podophyllotoxin-related leukemias.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Bleomycin / administration & dosage
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Cisplatin / administration & dosage
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Cytoplasm / immunology
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Etoposide / administration & dosage
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Gene Rearrangement*
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Humans
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Immunoglobulin Heavy Chains / analysis
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Immunoglobulin Heavy Chains / genetics*
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Immunoglobulins / analysis*
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Immunohistochemistry
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Leukemia, Monocytic, Acute / etiology
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Leukemia, Monocytic, Acute / genetics*
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Leukemia, Monocytic, Acute / immunology
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Male
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Seminoma / complications*
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Seminoma / drug therapy
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Testicular Neoplasms / complications*
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Testicular Neoplasms / drug therapy
Substances
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Immunoglobulin Heavy Chains
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Immunoglobulins
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Bleomycin
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Etoposide
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Cisplatin