Amplification of the MET gene in glioma

U Fischer; H W Müller; H P Sattler; K Feiden; K D Zang; E Meese

doi:10.1002/gcc.2870120111

Amplification of the MET gene in glioma

Genes Chromosomes Cancer. 1995 Jan;12(1):63-5. doi: 10.1002/gcc.2870120111.

Authors

U Fischer¹, H W Müller, H P Sattler, K Feiden, K D Zang, E Meese

Affiliation

¹ Department of Human Genetics, University of Saar, Homburg, Germany.

PMID: 7534113
DOI: 10.1002/gcc.2870120111

Abstract

We have previously reported the finding of MET amplification linked to double minutes (dmins) in a human glioblastoma (TX3095). Because dmins are found in approximately 50% of glioblastomas, 18 gliomas were analyzed for MET amplification. Three grade IV glioblastomas and one grade II astrocytoma showed amplification. We could also localize the MET amplicon to dmins in glioblastoma TX3095 by fluorescence in situ hybridization.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Base Sequence
Brain Neoplasms / genetics*
Gene Amplification*
Glioma / genetics*
Humans
Molecular Sequence Data