CD40 ligand/CD40 deficiency

Int Arch Allergy Immunol. 1995 May-Jun;107(1-3):37-9. doi: 10.1159/000236923.

Abstract

CD40 is a surface antigen expressed on B cells. The CD40 ligand (CD40L) is expressed on activated T cells. Interaction between CD40 and CD40L is critical for proliferation and isotype switching in the context of a response to a T-cell-dependent antigen. Patients with X-linked hyper-IgM syndrome (HIGMX-1) in their CD40L gene are unable to switch from IgM to IgG, IgA and IgE. Mice with a disrupted CD40 gene fail to undergo isotype switching to T-cell-dependent antigens but respond normally to T-independent antigens.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigens, CD / genetics*
  • Antigens, CD / physiology
  • Antigens, Differentiation, B-Lymphocyte / genetics*
  • Antigens, Differentiation, B-Lymphocyte / physiology
  • Antigens, T-Independent / immunology
  • B-Lymphocytes / immunology
  • Blastocyst
  • CD40 Antigens
  • CD40 Ligand
  • Chimera
  • Humans
  • Hypergammaglobulinemia / genetics*
  • Hypergammaglobulinemia / immunology
  • Immunoglobulin Class Switching* / genetics
  • Immunoglobulin M / biosynthesis*
  • Infant, Newborn / immunology*
  • Lymphocyte Activation
  • Lymphocyte Cooperation* / genetics
  • Membrane Glycoproteins / deficiency*
  • Membrane Glycoproteins / genetics
  • Membrane Glycoproteins / physiology
  • Mice
  • Mice, Knockout
  • Stem Cell Transplantation
  • T-Lymphocytes / immunology
  • Transcription, Genetic
  • X Chromosome

Substances

  • Antigens, CD
  • Antigens, Differentiation, B-Lymphocyte
  • Antigens, T-Independent
  • CD40 Antigens
  • Immunoglobulin M
  • Membrane Glycoproteins
  • CD40 Ligand