Abstract
CD40 is a surface antigen expressed on B cells. The CD40 ligand (CD40L) is expressed on activated T cells. Interaction between CD40 and CD40L is critical for proliferation and isotype switching in the context of a response to a T-cell-dependent antigen. Patients with X-linked hyper-IgM syndrome (HIGMX-1) in their CD40L gene are unable to switch from IgM to IgG, IgA and IgE. Mice with a disrupted CD40 gene fail to undergo isotype switching to T-cell-dependent antigens but respond normally to T-independent antigens.
MeSH terms
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Animals
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Antigens, CD / genetics*
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Antigens, CD / physiology
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Antigens, Differentiation, B-Lymphocyte / genetics*
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Antigens, Differentiation, B-Lymphocyte / physiology
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Antigens, T-Independent / immunology
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B-Lymphocytes / immunology
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Blastocyst
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CD40 Antigens
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CD40 Ligand
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Chimera
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Humans
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Hypergammaglobulinemia / genetics*
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Hypergammaglobulinemia / immunology
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Immunoglobulin Class Switching* / genetics
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Immunoglobulin M / biosynthesis*
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Infant, Newborn / immunology*
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Lymphocyte Activation
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Lymphocyte Cooperation* / genetics
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Membrane Glycoproteins / deficiency*
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Membrane Glycoproteins / genetics
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Membrane Glycoproteins / physiology
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Mice
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Mice, Knockout
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Stem Cell Transplantation
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T-Lymphocytes / immunology
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Transcription, Genetic
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X Chromosome
Substances
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Antigens, CD
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Antigens, Differentiation, B-Lymphocyte
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Antigens, T-Independent
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CD40 Antigens
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Immunoglobulin M
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Membrane Glycoproteins
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CD40 Ligand