Insulin-like growth factor 2 and insulin-like growth factor binding protein 2 expression in hepatoblastoma

S N Akmal; K Yun; J MacLay; Y Higami; T Ikeda

doi:10.1016/0046-8177(95)90005-5

Insulin-like growth factor 2 and insulin-like growth factor binding protein 2 expression in hepatoblastoma

Hum Pathol. 1995 Aug;26(8):846-51. doi: 10.1016/0046-8177(95)90005-5.

Authors

S N Akmal¹, K Yun, J MacLay, Y Higami, T Ikeda

Affiliation

¹ Department of Pathology, University of Otago Medical School, Dunedin, New Zealand.

PMID: 7543440
DOI: 10.1016/0046-8177(95)90005-5

Abstract

The expression of insulin-like growth factor 2 (IGF2) and insulin-like growth factor binding protein 2 (IGFBP2) in 11 cases of hepatoblastoma was studied by means of in situ mRNA hybridization using digoxigenin (DIG)-labeled riboprobes. The results showed that both IGF2 and IGFBP2 transcripts are present in hepatoblastoma and that their expression is inversely correlated with the degree of tumor cell differentiation. The data suggested that IGF2 and IGFBP2 gene expression could be regarded as a marker for assessment of the degree of differentiation in hepatoblastoma.

MeSH terms

Carrier Proteins / genetics*
Child, Preschool
Female
Gene Expression
Hepatoblastoma / genetics*
Humans
In Situ Hybridization
Infant
Insulin-Like Growth Factor Binding Protein 2
Insulin-Like Growth Factor II / genetics*
Liver / metabolism
Liver Neoplasms / genetics*
Male
RNA, Messenger / biosynthesis

Substances

Carrier Proteins
Insulin-Like Growth Factor Binding Protein 2
RNA, Messenger
Insulin-Like Growth Factor II