Abstract
MLN 50 was previously identified in a cDNA library of breast cancer metastasis. In this study, we show that MLN 50, which is expressed at a basal level in normal tissues, is overexpressed in 8% of human breast carcinomas most often together with c-erbB-2. MLN 50 cDNA encodes a putative protein of 261 residues, named Lasp-1 (LIM and SH3 protein) since it contains a LIM motif and a domain of Src homology region 3 (SH3) at the amino- and the C-terminal parts of the protein, respectively. Thus, Lasp-1 defines a new LIM protein subfamily.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adaptor Proteins, Signal Transducing
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Amino Acid Sequence
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Base Sequence
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Blotting, Northern
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Breast Neoplasms / metabolism*
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Chromosomes, Human, Pair 17
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Consensus Sequence / genetics
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Cytoskeletal Proteins
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DNA, Complementary / genetics
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Female
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Gene Expression
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Homeodomain Proteins / biosynthesis
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Homeodomain Proteins / chemistry*
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Homeodomain Proteins / genetics
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Humans
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LIM Domain Proteins
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Molecular Sequence Data
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Neoplasm Metastasis
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Neoplasm Proteins*
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Protein Kinases / genetics
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RNA, Messenger / biosynthesis
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RNA, Messenger / genetics
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Receptor, ErbB-2 / biosynthesis
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Sequence Alignment
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Sequence Homology, Amino Acid
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src Homology Domains*
Substances
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Adaptor Proteins, Signal Transducing
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Cytoskeletal Proteins
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DNA, Complementary
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Homeodomain Proteins
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LASP1 protein, human
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LIM Domain Proteins
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Neoplasm Proteins
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RNA, Messenger
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Protein Kinases
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Receptor, ErbB-2