The expression of the imprinted H19 and IGF-2 genes in human bladder carcinoma

M Elkin; A Shevelev; E Schulze; M Tykocinsky; M Cooper; I Ariel; D Pode; E Kopf; N de Groot; A Hochberg

doi:10.1016/0014-5793(95)01074-o

The expression of the imprinted H19 and IGF-2 genes in human bladder carcinoma

FEBS Lett. 1995 Oct 23;374(1):57-61. doi: 10.1016/0014-5793(95)01074-o.

Authors

M Elkin¹, A Shevelev, E Schulze, M Tykocinsky, M Cooper, I Ariel, D Pode, E Kopf, N de Groot, A Hochberg

Affiliation

¹ Department of Biological Chemistry, Silberman Institute of Life Sciences, Hebrew University, Jerusalem, Israel.

PMID: 7589512
DOI: 10.1016/0014-5793(95)01074-o

Abstract

The imprinted H19 gene is highly expressed in human embryos, fetal tissues and is nearly completely shut off in adults. However, it is reexpressed in a number of tumors including bladder carcinoma, demonstrating that H19 RNA is an oncofetal RNA. Tumors induced by injection of bladder carcinoma cell lines express H19 in contrast to the cells before injection. These observations support the notion of a positive correlation between H19 expression and bladder carcinoma. Loss of imprinting of H19 and IGF-2 was observed in samples of human bladder carcinoma.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Animals
Base Sequence
DNA Primers
Female
Gene Expression Regulation, Neoplastic*
Genomic Imprinting*
Humans
Insulin-Like Growth Factor II / genetics*
Mice
Mice, Nude
Molecular Sequence Data
Muscle Proteins / genetics*
Neoplasm Transplantation
RNA, Long Noncoding
RNA, Messenger / metabolism
RNA, Neoplasm / metabolism
RNA, Untranslated*
Transplantation, Heterologous
Tumor Cells, Cultured
Urinary Bladder Neoplasms / genetics*

Substances

DNA Primers
H19 long non-coding RNA
Muscle Proteins
RNA, Long Noncoding
RNA, Messenger
RNA, Neoplasm
RNA, Untranslated
Insulin-Like Growth Factor II