The role of hsp90 in SLE

Autoimmunity. 1994;19(3):211-8. doi: 10.3109/08916939408995696.

Abstract

The heat shock proteins are a group of evolutionarily conserved proteins with important physiological functions, whose synthesis is enhanced by elevated temperature or other stresses. A role for one or more of these proteins in human autoimmune disease has been extensively discussed. This review considers the evidence of a role for hsp90 in systemic lupus erythematosus (SLE) where overexpression of this protein, its surface localization and auto-antibodies to it have been observed in both human patients and in the MRL/lpr mouse model of SLE.

Publication types

  • Review

MeSH terms

  • Animals
  • Autoantibodies / immunology*
  • Autoantigens / biosynthesis
  • Autoantigens / genetics
  • Autoantigens / immunology*
  • Autoimmune Diseases / genetics
  • Autoimmune Diseases / immunology*
  • Disease Models, Animal
  • Disease Susceptibility / immunology
  • Gene Expression Regulation
  • Genetic Predisposition to Disease
  • HLA-A1 Antigen / genetics
  • HLA-B8 Antigen / genetics
  • HLA-DR3 Antigen / genetics
  • HSP90 Heat-Shock Proteins / biosynthesis
  • HSP90 Heat-Shock Proteins / genetics
  • HSP90 Heat-Shock Proteins / immunology*
  • Haplotypes / immunology
  • Humans
  • Lupus Erythematosus, Systemic / genetics
  • Lupus Erythematosus, Systemic / immunology*
  • Lymphoproliferative Disorders / genetics
  • Lymphoproliferative Disorders / immunology
  • Mice
  • Mice, Mutant Strains
  • Models, Immunological

Substances

  • Autoantibodies
  • Autoantigens
  • HLA-A1 Antigen
  • HLA-B8 Antigen
  • HLA-DR3 Antigen
  • HSP90 Heat-Shock Proteins