Abstract
The heat shock proteins are a group of evolutionarily conserved proteins with important physiological functions, whose synthesis is enhanced by elevated temperature or other stresses. A role for one or more of these proteins in human autoimmune disease has been extensively discussed. This review considers the evidence of a role for hsp90 in systemic lupus erythematosus (SLE) where overexpression of this protein, its surface localization and auto-antibodies to it have been observed in both human patients and in the MRL/lpr mouse model of SLE.
MeSH terms
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Animals
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Autoantibodies / immunology*
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Autoantigens / biosynthesis
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Autoantigens / genetics
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Autoantigens / immunology*
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Autoimmune Diseases / genetics
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Autoimmune Diseases / immunology*
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Disease Models, Animal
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Disease Susceptibility / immunology
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Gene Expression Regulation
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Genetic Predisposition to Disease
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HLA-A1 Antigen / genetics
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HLA-B8 Antigen / genetics
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HLA-DR3 Antigen / genetics
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HSP90 Heat-Shock Proteins / biosynthesis
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HSP90 Heat-Shock Proteins / genetics
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HSP90 Heat-Shock Proteins / immunology*
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Haplotypes / immunology
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Humans
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Lupus Erythematosus, Systemic / genetics
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Lupus Erythematosus, Systemic / immunology*
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Lymphoproliferative Disorders / genetics
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Lymphoproliferative Disorders / immunology
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Mice
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Mice, Mutant Strains
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Models, Immunological
Substances
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Autoantibodies
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Autoantigens
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HLA-A1 Antigen
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HLA-B8 Antigen
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HLA-DR3 Antigen
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HSP90 Heat-Shock Proteins