Abstract
The hypothesis of 35 years ago that slowreacting substance of anaphylaxis would prove to be a pathobiologic mediator of reversible airway disease in the human has been validated. The multidisciplinary approach required to achieve this goal has been particularly prominent and consistent for the entire period in the program described in this presentation.
Publication types
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Autobiography
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Biography
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Historical Article
MeSH terms
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Airway Obstruction / etiology
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Anaphylaxis / complications
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Anaphylaxis / immunology*
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Anaphylaxis / physiopathology
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Animals
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Cloning, Molecular
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Fish Oils / pharmacology
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Fish Oils / therapeutic use
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Genes
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Glutathione Transferase / genetics
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Glutathione Transferase / history*
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Glutathione Transferase / physiology
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Guinea Pigs
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Haplorhini
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History, 20th Century
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Humans
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Leukotriene C4 / biosynthesis
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Leukotriene C4 / physiology
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London
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Lung / physiopathology
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Massachusetts
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Rats
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SRS-A / history*
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SRS-A / physiology
Substances
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Fish Oils
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SRS-A
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Leukotriene C4
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Glutathione Transferase
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leukotriene-C4 synthase