Sequence homology of rat and human HCNP precursor proteins, bovine phosphatidylethanolamine-binding protein and rat 23-kDa protein associated with the opioid-binding protein

N Tohdoh; S Tojo; H Agui; K Ojika

doi:10.1016/0169-328x(95)00029-r

Sequence homology of rat and human HCNP precursor proteins, bovine phosphatidylethanolamine-binding protein and rat 23-kDa protein associated with the opioid-binding protein

Brain Res Mol Brain Res. 1995 Jun;30(2):381-4. doi: 10.1016/0169-328x(95)00029-r.

Authors

N Tohdoh¹, S Tojo, H Agui, K Ojika

Affiliation

¹ Discovery Research Laboratories III, Sumitomo Pharmaceuticals Research Center, Osaka, Japan.

PMID: 7637590
DOI: 10.1016/0169-328x(95)00029-r

Abstract

The hippocampal cholinergic neurostimulating peptide (HCNP) enhances acetylcholine synthesis in rat medial septal tissues. We have cloned the cDNAs of the precursor proteins of rat and human HCNP and deduced their respective amino acid sequences. The HCNP sequences aligned at the N-terminal regions of their precursors. The deduced amino acid sequences showed homology with those of the bovine brain phosphatidylethanolamine-binding protein and the rat protein associated with the opioid-binding protein. These observations suggest that the HCNP precursor proteins may have multiple functions.

MeSH terms

Acetylcholine / biosynthesis
Amino Acid Sequence
Animals
Base Sequence
Carrier Proteins / genetics*
Cattle
Cholinergic Agents / metabolism*
DNA, Complementary
Humans
Molecular Sequence Data
Neuropeptides / genetics
Neuropeptides / metabolism*
Phosphatidylethanolamines / metabolism*
Protein Precursors / metabolism*
Rats
Receptors, Opioid / metabolism*

Substances

Carrier Proteins
Cholinergic Agents
DNA, Complementary
Neuropeptides
Phosphatidylethanolamines
Protein Precursors
Receptors, Opioid
hippocampal cholinergic neurostimulating peptide
Acetylcholine

Associated data

GENBANK/X75252
GENBANK/X75253
PIR/S00056