HLA class II typing and idiopathic IgA nephropathy (IgAN): DQB1*0301, a possible marker of unfavorable outcome

O Raguénès; B Mercier; J Clèdes; B Whebe; C Férec

doi:10.1111/j.1399-0039.1995.tb02447.x

HLA class II typing and idiopathic IgA nephropathy (IgAN): DQB1*0301, a possible marker of unfavorable outcome

Tissue Antigens. 1995 Apr;45(4):246-9. doi: 10.1111/j.1399-0039.1995.tb02447.x.

Authors

O Raguénès¹, B Mercier, J Clèdes, B Whebe, C Férec

Affiliation

¹ Centre de Biogénétique, Centre Départemental de Transfusion Sanguine, Brest, France.

PMID: 7638860
DOI: 10.1111/j.1399-0039.1995.tb02447.x

Abstract

Previous studies have reported associations between HLA antigens and Idiopathic IgA Nephropathy (IgAN). Nevertheless most of the studies were performed by serology. Thus we decided to perform the HLA class II typing of 58 patients by molecular biology techniques. We report a small increase of DRB1*04. But the main result of our study is the identification of a strong association between HLA DQB1*0301 and IgAN patients with an unfavorable outcome.

MeSH terms

Gene Frequency
Genetic Markers
Glomerulonephritis, IGA / genetics
Glomerulonephritis, IGA / immunology*
HLA-DP Antigens
HLA-DP beta-Chains
HLA-DQ Antigens / analysis*
HLA-DQ alpha-Chains
HLA-DQ beta-Chains
HLA-DR Antigens
HLA-DRB1 Chains
Histocompatibility Testing
Humans
Prognosis

Substances

Genetic Markers
HLA-DP Antigens
HLA-DP beta-Chains
HLA-DPB1 antigen
HLA-DQ Antigens
HLA-DQ alpha-Chains
HLA-DQ beta-Chains
HLA-DQA1 antigen
HLA-DQB1 antigen
HLA-DR Antigens
HLA-DRB1 Chains