Sequence of an exon of tumour suppressor p53 gene--a comparative study in domestic animals: mutation in a feline solid mammary carcinoma

B Mayr; G Schaffner; R Kurzbauer; M Reifinger; K Schellander

doi:10.1016/s0007-1935(95)80183-9

Sequence of an exon of tumour suppressor p53 gene--a comparative study in domestic animals: mutation in a feline solid mammary carcinoma

Br Vet J. 1995 May-Jun;151(3):325-9. doi: 10.1016/s0007-1935(95)80183-9.

Authors

B Mayr¹, G Schaffner, R Kurzbauer, M Reifinger, K Schellander

Affiliation

¹ Institute for Animal Breeding and Genetics, Veterinary University, Vienna, Austria.

PMID: 7640960
DOI: 10.1016/s0007-1935(95)80183-9

Abstract

Partial sequence determinations were performed on exon 8 of tumour suppressor gene p53 of cattle, sheep, goat, horse and pig. High sequence homology between these species and other species including dog, cat, chicken and man is demonstrated. A mutation CGG-->TGG (arginine-->tryptophan) was detected in a feline solid carcinoma of the mammary gland.

Publication types

Comparative Study

MeSH terms

Animals
Animals, Domestic / genetics*
Base Sequence
Cat Diseases / genetics*
Cat Diseases / pathology
Cats
DNA Primers / chemistry
DNA, Neoplasm / analysis
Exons*
Genes, p53 / genetics*
Humans
Mammary Neoplasms, Animal / genetics*
Mammary Neoplasms, Animal / pathology
Molecular Sequence Data
Mutation / genetics*
Polymerase Chain Reaction / veterinary
Sequence Homology, Nucleic Acid

Substances

DNA Primers
DNA, Neoplasm