Abstract
Hypoglycemia occurred in a 2-year-old girl with neuroblastoma. Initially, growth hormone secretion was suppressed, and she had low levels of insulin-like growth factor (IGF)-I and IGF binding protein-3, but elevated levels of large molecular weight IGF-II. We postulated that the pathogenesis of her hypoglycemia involved production of IGF-II by her neuroblastoma, leading to GH suppression and an abnormally elevated ratio of IGF to IGF binding protein. She was successfully treated with growth hormone; treatment was associated with normalization of the growth hormone-dependent growth factor levels and with euglycemia.
Publication types
-
Case Reports
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
-
Review
MeSH terms
-
Adenoma, Islet Cell
-
Adrenal Gland Neoplasms / complications*
-
Adrenal Gland Neoplasms / genetics
-
Adrenal Gland Neoplasms / therapy
-
Blood Glucose / analysis
-
Child, Preschool
-
Combined Modality Therapy
-
Female
-
Growth Hormone / therapeutic use*
-
Humans
-
Hypoglycemia / blood
-
Hypoglycemia / drug therapy*
-
Hypoglycemia / etiology
-
Insulin-Like Growth Factor I / analysis
-
Insulin-Like Growth Factor II / analysis
-
Neoplasm Recurrence, Local / complications
-
Neoplasm Recurrence, Local / genetics
-
Neoplasm Recurrence, Local / therapy
-
Neuroblastoma / complications*
-
Neuroblastoma / genetics
-
Neuroblastoma / therapy
-
Pancreatic Neoplasms
-
Time Factors
Substances
-
Blood Glucose
-
Insulin-Like Growth Factor I
-
Insulin-Like Growth Factor II
-
Growth Hormone