Abstract
Expression of the CD15 antigen, which is one of the adhesion molecules, was studied immunohistochemically to investigate the mechanism of intrahepatic metastasis in 56 hepatocellular carcinomas (HCC). Twenty-nine percent (16 of 56) of the HCC expressed CD15. No noncancerous hepatocytes expressed CD15. CD15-positive HCC had histologic intrahepatic metastasis more often than did CD15-negative HCC; the difference was statistically significant (P < 0.02). The survival rate of patients with CD15-negative HCC was better than that of patients with CD15-positive HCC, although the difference was not statistically significant. The authors speculate that there is a relationship between the expression of CD15 and intrahepatic metastasis in HCC.
MeSH terms
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Antigens, CD / analysis
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Antigens, CD / genetics*
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Antigens, Differentiation, Myelomonocytic / analysis
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Antigens, Differentiation, Myelomonocytic / genetics*
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Biomarkers, Tumor / analysis
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Biomarkers, Tumor / genetics*
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Carcinoma, Hepatocellular / genetics*
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Carcinoma, Hepatocellular / immunology
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Carcinoma, Hepatocellular / pathology
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Carcinoma, Hepatocellular / secondary
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Carcinoma, Hepatocellular / surgery
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Cell Membrane / immunology
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Female
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Gene Expression
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Hepatectomy / methods
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Humans
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Lewis X Antigen
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Liver Neoplasms / genetics*
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Liver Neoplasms / immunology
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Liver Neoplasms / pathology
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Liver Neoplasms / secondary
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Liver Neoplasms / surgery
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Male
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Middle Aged
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Staining and Labeling
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Survival Rate
Substances
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Antigens, CD
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Antigens, Differentiation, Myelomonocytic
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Biomarkers, Tumor
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Lewis X Antigen