Abstract
The presence of anti-E2 antibody was investigated in the serum samples of 46 patients with liver disease, who were positive for hepatitis C virus-RNA, and in five subjects HCV-RNA-negative acting as controls. Antibody to E2/NS1 protein was found in seven of 46 (15%) of the patients with liver disease but in none of the control subjects. In one patient who was treated successfully with interferon, the levels of anti-E2 gradually decreased and then finally disappeared after treatment. This suggests that the E2/NS1 protein may play a role in active viral replication.
MeSH terms
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ATP-Binding Cassette Transporters*
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Blotting, Western
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Carrier Proteins / genetics
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Chronic Disease
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Escherichia coli
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Escherichia coli Proteins*
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Gene Expression / genetics
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Hepacivirus / immunology*
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Hepatitis Antibodies / blood*
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Hepatitis C / immunology*
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Hepatitis C Antibodies
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Humans
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Maltose-Binding Proteins
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Monosaccharide Transport Proteins*
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Polymerase Chain Reaction
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Transfection
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Viral Envelope Proteins / genetics
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Viral Envelope Proteins / immunology
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Viral Envelope Proteins / isolation & purification*
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Viral Fusion Proteins / genetics
Substances
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ATP-Binding Cassette Transporters
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Carrier Proteins
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Escherichia coli Proteins
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Hepatitis Antibodies
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Hepatitis C Antibodies
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Maltose-Binding Proteins
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Monosaccharide Transport Proteins
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Viral Envelope Proteins
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Viral Fusion Proteins
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maltose transport system, E coli