Abstract
We investigated the synergistic efficacy of CDDP and UFT, an oral anticancer derivative of 5-fluorouracil, on DNA synthesis of 3'-MeDAB-induced hepatocarcinomas in rats. Chronic treatment with CDDP slightly reduced tissue activities of thymidylate synthetase and thymidine kinase in the hepatocarcinomas, and, moreover, simultaneous administration of a low dose of UFT with CDDP markedly suppressed both enzyme activities, i.e., UFT and CDDP showed a potent synergism on DNA synthesis in hepatocarcinomas.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Oral
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Animals
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Cisplatin / pharmacology*
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DNA, Neoplasm / biosynthesis
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DNA, Neoplasm / drug effects*
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Drug Synergism
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Liver / enzymology*
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Liver Neoplasms, Experimental / chemically induced
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Liver Neoplasms, Experimental / enzymology
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Liver Neoplasms, Experimental / metabolism*
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Male
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Methyldimethylaminoazobenzene
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Rats
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Thymidine Kinase / biosynthesis*
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Thymidylate Synthase / biosynthesis*
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Uracil / administration & dosage
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Uracil / pharmacology*
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alpha-Fetoproteins / biosynthesis
Substances
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DNA, Neoplasm
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alpha-Fetoproteins
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Methyldimethylaminoazobenzene
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Uracil
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Thymidylate Synthase
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Thymidine Kinase
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Cisplatin