Abstract
Pineal ganglioglioma was diagnosed in a 36-year-old man with familial basal ganglia calcification and elevated serum alpha-fetoprotein. The patient was treated surgically with a good result. Only four other cases of this tumor have been reported. His 38-year-old brother also showed basal ganglia calcification and elevated serum chorionic gonadotropin as well as alpha-fetoprotein. Familial basal ganglia calcification with elevated serum alpha-fetoprotein in a nonhepatic benign condition is rare. The pathogenesis of these conditions is discussed.
MeSH terms
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Adult
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Basal Ganglia Diseases / diagnosis
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Basal Ganglia Diseases / genetics*
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Basal Ganglia Diseases / pathology
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Basal Ganglia Diseases / surgery
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Calcinosis / diagnosis
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Calcinosis / genetics*
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Calcinosis / pathology
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Calcinosis / surgery
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Chromosome Aberrations / genetics
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Chromosome Disorders
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Ganglioglioma / diagnosis
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Ganglioglioma / genetics*
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Ganglioglioma / pathology
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Ganglioglioma / surgery
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Genes, Dominant / genetics
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Humans
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Magnetic Resonance Imaging
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Male
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Microscopy, Electron
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Pineal Gland* / pathology
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Pineal Gland* / surgery
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Tomography, X-Ray Computed
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alpha-Fetoproteins / metabolism*