Abstract
Genetic factors related to the development of alcoholic liver and pancreatic diseases (ALD and APD) and of alcohol-induced asthma were analyzed. The development of ALD is genetically controlled and is directly associated with the polymorphisms of the genes of acetaldehyde (Ac-CHO) and ethanol-metabolizing enzymes, aldehyde dehydrogenase-2 (ALDH2) and cytochrome P4502E1. The development of ALD and APD may also be genetically linked with the induction of gamma-glutamyl transferase (GTT) by alcohol. Alcohol-induced asthma is related to the genotypes of ALDH2 and is caused by rapid elevation of blood Ac-CHO. ALDH1 plays a very important role in the oxidation of Ac-CHO in blood.
MeSH terms
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Acetaldehyde / blood
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Aldehyde Dehydrogenase / genetics*
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Asthma / enzymology
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Asthma / genetics
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Cytochrome P-450 CYP2E1
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Cytochrome P-450 Enzyme System / genetics
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Enzyme Induction / genetics
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Genetic Linkage
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Genotype*
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Humans
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Isoenzymes / genetics*
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Liver Diseases, Alcoholic / enzymology
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Liver Diseases, Alcoholic / genetics*
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Lung Diseases, Obstructive / enzymology
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Lung Diseases, Obstructive / genetics*
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Oxidoreductases, N-Demethylating / genetics
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Polymorphism, Genetic / genetics*
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Risk Factors
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gamma-Glutamyltransferase / genetics
Substances
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Isoenzymes
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Cytochrome P-450 Enzyme System
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Cytochrome P-450 CYP2E1
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Aldehyde Dehydrogenase
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Oxidoreductases, N-Demethylating
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gamma-Glutamyltransferase
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Acetaldehyde