Localization of the gene for congenital dyserythropoietic anemia type III, CDAN3, to chromosome 15q21-q25

Hum Mol Genet. 1995 Jan;4(1):109-12. doi: 10.1093/hmg/4.1.109.

Abstract

Congenital dyserythropoietic anemia, type III (CDA III) is a rare autosomal dominant disorder characterized by macrocytic anemia, bone marrow erythroid hyperplasia and giant multinucleate erythroblasts. We have genetically characterized a large Swedish family in which the concurrence of CDA III and myeloma or benign monoclonal gammopathy is significantly higher than expected and have found that the causative genetic defect for CDA III maps to an 11 cM interval within 15q21-q25.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anemia, Dyserythropoietic, Congenital / genetics*
  • Chromosome Mapping
  • Chromosomes, Human, Pair 15*
  • Female
  • Genetic Linkage
  • Humans
  • Male
  • Pedigree