Abstract
Six kindreds containing multiple cases of manic-depressive illness were genotyped with highly polymorphic microsatellite polymorphisms for the D5 dopamine and alpha 2C-adrenergic receptor genes. Evidence of linkage was not found assuming either autosomal dominant or recessive transmission. The non-parametric sib pair test did not yield evidence of linkage.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alleles
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Bipolar Disorder / genetics*
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Genetic Linkage
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Genetic Markers
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Humans
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Lod Score
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Nuclear Family
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Pedigree
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Receptors, Adrenergic, alpha-2 / genetics*
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Receptors, Dopamine / genetics*
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Receptors, Dopamine D1*
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Receptors, Dopamine D5
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Regression Analysis
Substances
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ADRA2C protein, human
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DRD5 protein, human
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Genetic Markers
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Receptors, Adrenergic, alpha-2
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Receptors, Dopamine
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Receptors, Dopamine D1
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Receptors, Dopamine D5