Study of the possible association of HLA class II, CD4, and CD3 polymorphisms with schizophrenia

Am J Med Genet. 1994 Dec 15;54(4):372-7. doi: 10.1002/ajmg.1320540417.

Abstract

In the present study the HLA-DRB and DPB1 alleles as well as CD4 and CD3 polymorphisms were tested in 100 Belgian schizophrenic patients and 204 controls. Our results indicate a significant negative association of the DPB1 0101 allele with schizophrenia (relative risk [RR] = 0.27). Furthermore a significant positive and negative association could be noticed for the CD4*A4 allele and CD4*A7/A8 genotype, respectively (RR 1.79 and 0.47, respectively). These findings suggest that some contribution of HLA class II and CD4 genes to an autoimmune-like pathogenesis in schizophrenia might exist.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Age of Onset
  • Aged
  • Alleles
  • Antigens, CD / genetics*
  • Base Sequence
  • CD3 Complex / genetics*
  • CD4 Antigens / genetics*
  • Child
  • DNA Primers
  • Female
  • HLA-D Antigens / genetics*
  • HLA-DR Antigens / genetics
  • HLA-DRB1 Chains
  • Humans
  • Male
  • Middle Aged
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • Polymorphism, Genetic*
  • Reference Values
  • Schizophrenia / genetics*
  • Schizophrenia / immunology
  • Sex Factors

Substances

  • Antigens, CD
  • CD3 Complex
  • CD4 Antigens
  • DNA Primers
  • HLA-D Antigens
  • HLA-DR Antigens
  • HLA-DRB1 Chains