Solid alveolar rhabdomyosarcoma with a t(2;13)

S M Yule; N Bown; A J Malcolm; M M Reid; A D Pearson

doi:10.1016/0165-4608(94)00170-g

Solid alveolar rhabdomyosarcoma with a t(2;13)

Cancer Genet Cytogenet. 1995 Apr;80(2):107-9. doi: 10.1016/0165-4608(94)00170-g.

Authors

S M Yule¹, N Bown, A J Malcolm, M M Reid, A D Pearson

Affiliation

¹ Department of Child Health, Medical School, Newcastle upon Tyne, U.K.

PMID: 7736424
DOI: 10.1016/0165-4608(94)00170-g

Abstract

We report a child with a progressive "solid alveolar rhabdomyosarcoma" in whom analysis of tumor cells revealed a t(2;13) translocation characteristic of the classical alveolar subtype. Both subtypes of alveolar rhabdomyosarcoma are associated with a poor response to treatment and the occurrence of this translocation in both is suggestive of a common biologic origin.

Publication types

Case Reports

MeSH terms

Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Child, Preschool
Chromosomes, Human, Pair 13*
Chromosomes, Human, Pair 2*
Combined Modality Therapy
Humans
Rhabdomyosarcoma, Alveolar / drug therapy
Rhabdomyosarcoma, Alveolar / genetics*
Rhabdomyosarcoma, Alveolar / radiotherapy
Translocation, Genetic*