Abstract
We have identified a G-protein-coupled receptor specifically activated by parathyroid hormone, which we refer to as the PTH2 receptor. Parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP, hypercalcemia of malignancy factor) activate a previously identified PTH/PTHrP receptor, which has a widespread tissue distribution. The PTH2 receptor is much more selective in ligand recognition and appears to have a more specific tissue distribution. It is activated by PTH and not by PTHrP and is particularly abundant in the brain and pancreas.
MeSH terms
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Amino Acid Sequence
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Base Sequence
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Humans
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Molecular Sequence Data
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Parathyroid Hormone / pharmacology
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Parathyroid Hormone-Related Protein
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Proteins / pharmacology
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RNA, Messenger / analysis
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Receptor, Parathyroid Hormone, Type 1
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Receptors, Parathyroid Hormone / analysis*
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Receptors, Parathyroid Hormone / chemistry
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Receptors, Parathyroid Hormone / genetics
Substances
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PTHLH protein, human
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Parathyroid Hormone
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Parathyroid Hormone-Related Protein
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Proteins
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RNA, Messenger
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Receptor, Parathyroid Hormone, Type 1
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Receptors, Parathyroid Hormone
Associated data
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GENBANK/U25128
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GENBANK/U47124
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GENBANK/U47125
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GENBANK/U47126
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GENBANK/U47127
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GENBANK/U47128
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GENBANK/U47129