Do mutations at the glycophorin A locus in patients treated for childhood Hodgkin's disease predict secondary leukaemia?

M G Mott; J Boyse; M Hewitt; M Radford

doi:10.1016/s0140-6736(94)92027-3

Do mutations at the glycophorin A locus in patients treated for childhood Hodgkin's disease predict secondary leukaemia?

Lancet. 1994 Apr 2;343(8901):828-9. doi: 10.1016/s0140-6736(94)92027-3.

Authors

M G Mott¹, J Boyse, M Hewitt, M Radford

Affiliation

¹ Institute of Child Health, Royal Hospital for Sick Children, Bristol, UK.

PMID: 7908079
DOI: 10.1016/s0140-6736(94)92027-3

Abstract

Childhood Hodgkin's disease has a high cure rate but second cancers are common, related to treatment and perhaps genetic predisposition. The glycophorin A (GPA) mutation assay measures the frequency of NO and NN mutant erythrocytes of MN blood-group heterozygous individuals. Mutant frequencies in Hodgkin's disease patients were compared with controls. No significant difference from controls was found pretreatment or in patients treated with radiotherapy only. Patients who received chemotherapy had a significantly increased frequency (total mutation frequency per 10(6) cells: 31 vs 11, p < 0.001), which may be relevant to their known increased risk of secondary leukaemia.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Child
Female
Glycophorins / genetics*
Hodgkin Disease / therapy*
Humans
Leukemia / etiology*
Leukemia, Radiation-Induced / diagnosis
Leukemia, Radiation-Induced / genetics
Male
Mutation* / drug effects
Mutation* / radiation effects
Neoplasms, Second Primary / diagnosis*
Neoplasms, Second Primary / genetics

Substances

Glycophorins