Alanine at position 73 of HLA-C is associated with psoriasis vulgaris in Finland

I Ikäheimo; S Silvennoinen-Kassinen; J Karvonen; A Tiilikainen

doi:10.1111/j.1365-2133.1994.tb08501.x

Alanine at position 73 of HLA-C is associated with psoriasis vulgaris in Finland

Br J Dermatol. 1994 Aug;131(2):257-9. doi: 10.1111/j.1365-2133.1994.tb08501.x.

Authors

I Ikäheimo¹, S Silvennoinen-Kassinen, J Karvonen, A Tiilikainen

Affiliation

¹ Department of Medical Microbiology, University of Oulu, Finland.

PMID: 7917991
DOI: 10.1111/j.1365-2133.1994.tb08501.x

Abstract

A close association was found between a specific sequence of HLA-C and psoriasis vulgaris in Finnish patients (chi 2 = 18.4, P = 1.78 x 10(-5)). This sequence codes for alanine at position 73 of the HLA-C molecule in the antigen binding cleft, and alanine may play a role in susceptibility to the disease.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alanine*
Base Sequence
DNA Primers
Disease Susceptibility
Finland
HLA-C Antigens / genetics*
Humans
Molecular Sequence Data
Oligonucleotide Probes
Psoriasis / genetics*

Substances

DNA Primers
HLA-C Antigens
Oligonucleotide Probes
Alanine