Abstract
Triggering of autoimmunity in insulin-dependent diabetes was linked to dietary bovine serum albumin (BSA). Anti-BSA antibodies from diabetes-prone rats precipitate a protein, p69, from islet cell lysates. We have used these antibodies to identify rat p69 cDNAs. Human p69 cDNA was identified by crosshybridization. The p69 coding regions show 87% nucleotide and 89% amino acid homology. Recombinant p69 is recognized by autoantibody and T cells from diabetic children.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Autoantigens / genetics*
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Autoantigens / immunology
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Autoimmunity
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Base Sequence
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Child
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Cloning, Molecular
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DNA, Complementary / genetics*
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Diabetes Mellitus, Type 1 / genetics*
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Diabetes Mellitus, Type 1 / immunology
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Humans
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Molecular Sequence Data
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Pancreas / metabolism*
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RNA, Messenger / analysis
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Rats
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Rats, Inbred BB
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Sequence Alignment
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Sequence Homology, Amino Acid
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Sequence Homology, Nucleic Acid
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Serum Albumin, Bovine / genetics
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Serum Albumin, Bovine / immunology
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T-Lymphocytes / immunology
Substances
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Autoantigens
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DNA, Complementary
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ICA1 protein, human
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Ica1 protein, rat
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RNA, Messenger
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Serum Albumin, Bovine
Associated data
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GENBANK/L20900
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GENBANK/L21181