Cloning of human and rat p69 cDNA, a candidate autoimmune target in type 1 diabetes

Biochim Biophys Acta. 1994 Oct 21;1227(1-2):101-4. doi: 10.1016/0925-4439(94)90113-9.

Abstract

Triggering of autoimmunity in insulin-dependent diabetes was linked to dietary bovine serum albumin (BSA). Anti-BSA antibodies from diabetes-prone rats precipitate a protein, p69, from islet cell lysates. We have used these antibodies to identify rat p69 cDNAs. Human p69 cDNA was identified by crosshybridization. The p69 coding regions show 87% nucleotide and 89% amino acid homology. Recombinant p69 is recognized by autoantibody and T cells from diabetic children.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Autoantigens / genetics*
  • Autoantigens / immunology
  • Autoimmunity
  • Base Sequence
  • Child
  • Cloning, Molecular
  • DNA, Complementary / genetics*
  • Diabetes Mellitus, Type 1 / genetics*
  • Diabetes Mellitus, Type 1 / immunology
  • Humans
  • Molecular Sequence Data
  • Pancreas / metabolism*
  • RNA, Messenger / analysis
  • Rats
  • Rats, Inbred BB
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Sequence Homology, Nucleic Acid
  • Serum Albumin, Bovine / genetics
  • Serum Albumin, Bovine / immunology
  • T-Lymphocytes / immunology

Substances

  • Autoantigens
  • DNA, Complementary
  • ICA1 protein, human
  • Ica1 protein, rat
  • RNA, Messenger
  • Serum Albumin, Bovine

Associated data

  • GENBANK/L20900
  • GENBANK/L21181