Alzheimer's disease. The apolipoprotein E connection

Curr Biol. 1994 Apr 1;4(4):362-5. doi: 10.1016/s0960-9822(00)00081-6.

Abstract

One particular variant of the polymorphic protein apolipoprotein E appears to be a risk factor for Alzheimer's disease, possibly because it directly promotes anyloid formation.

Publication types

  • Review

MeSH terms

  • Aged
  • Alleles
  • Alzheimer Disease / etiology
  • Alzheimer Disease / genetics*
  • Alzheimer Disease / metabolism
  • Amyloid / biosynthesis
  • Apolipoproteins E / genetics*
  • Apolipoproteins E / metabolism
  • Gene Frequency
  • Genetic Variation
  • Humans
  • Models, Biological
  • Neurofibrillary Tangles / metabolism
  • Risk Factors
  • tau Proteins / metabolism

Substances

  • Amyloid
  • Apolipoproteins E
  • tau Proteins