Abstract
The gene for human Elk-1, an Ets-related transcription factor, has previously been localized to a region that lies on the short arm of chromosome X and that is involved in specific chromosomal translocations associated with synovial sarcoma and renal adenocarcinomas. We have used fluorescence in situ hybridization and a panel of tumor-derived somatic cell hybrids to refine the localization of Elk-1, in particular with regard to the rearrangements in these tumors. Elk-1 has been assigned to Xp11.2-p11.4, distal to the OATL1 region.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Carcinoma, Renal Cell / genetics
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Chromosome Mapping*
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Cricetinae
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Cricetulus
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DNA-Binding Proteins*
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Female
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Gene Rearrangement
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Humans
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Hybrid Cells
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In Situ Hybridization, Fluorescence
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Kidney Neoplasms / genetics
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Proto-Oncogene Proteins*
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Retroviridae Proteins, Oncogenic / genetics*
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Sarcoma, Synovial / genetics
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Transcription Factors*
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Transcription, Genetic
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Translocation, Genetic
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X Chromosome*
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ets-Domain Protein Elk-1
Substances
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DNA-Binding Proteins
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ELK1 protein, human
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Proto-Oncogene Proteins
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Retroviridae Proteins, Oncogenic
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Transcription Factors
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ets-Domain Protein Elk-1