Apolipoprotein E epsilon 4 allele frequency in patients with Lewy body dementia, Alzheimer's disease and age-matched controls

Neurosci Lett. 1994 Jul 18;176(1):45-6. doi: 10.1016/0304-3940(94)90867-2.

Abstract

Genotypes of apolipoprotein E (ApoE) were determined by polymerase-chain reaction (PCR) amplification and restriction-sizing of brain DNA from 39 cases of Lewy body dementia (LBD), 68 senile Alzheimer's disease (AD) patients and 47 neuropathologically validated non-demented controls. There was a 3-fold increase in the epsilon 4 allele frequency in both LBD and AD groups compared with controls. These results indicate that LBD and AD share the epsilon 4 allele of ApoE as a major risk factor for the development of disease and suggest a similarity in disease aetiology.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alleles*
  • Alzheimer Disease / genetics*
  • Alzheimer Disease / metabolism
  • Apolipoprotein E4
  • Apolipoproteins E / biosynthesis
  • Apolipoproteins E / genetics*
  • Brain / metabolism*
  • DNA / analysis
  • Gene Frequency
  • Genotype
  • Humans
  • Parkinson Disease / genetics*
  • Parkinson Disease / metabolism
  • Polymerase Chain Reaction
  • Reference Values
  • Restriction Mapping

Substances

  • Apolipoprotein E4
  • Apolipoproteins E
  • DNA