Abstract
We studied the effects of human recombinant interleukin-1 alpha on scopolamine-induced amnesia for a passive avoidance response in the mouse. Post-training intraperitoneal administration of the cytokine (0.25 or 0.50 microgram/mouse) significantly reduced the amnesic effect of scopolamine (1.0 mg/kg i.p.). Our results indicate that peripheral interleukin-1 alpha can influence behavior and suggest the involvement of the cholinergic system in the neuromodulatory actions of this cytokine.
MeSH terms
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Amnesia / chemically induced*
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Amnesia / psychology
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Animals
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Avoidance Learning / drug effects
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Humans
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Injections, Intraperitoneal
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Interleukin-1 / administration & dosage
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Interleukin-1 / pharmacology*
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Male
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Mice
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Motor Activity / drug effects
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Parasympathetic Nervous System / drug effects
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Recombinant Proteins / administration & dosage
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Recombinant Proteins / pharmacology
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Scopolamine / antagonists & inhibitors*
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Scopolamine / pharmacology
Substances
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Interleukin-1
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Recombinant Proteins
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Scopolamine