Mapping of a quantitative trait locus for blood pressure on rat chromosome 2

J Clin Invest. 1994 Jul;94(1):431-6. doi: 10.1172/JCI117341.

Abstract

A genetic map for rat chromosome 2 that includes five candidate genes for blood pressure regulation was constructed in a region containing a quantitative trait locus (QTL) for blood pressure. Two F2 populations of male rats raised on high salt (8% NaCI) diet from weaning were studied: F2(WKY x S), derived from a cross of Dahl salt-sensitive rats (S) and Wistar-Kyoto rats (WKY); and F2(MNS x S), derived from a cross of S rats and Milan normotensive strain (MNS). In both populations a blood pressure QTL was localized between Na+,K(+)-ATPase alpha 1 isoform and calmodulin-dependent protein kinase II-delta loci. The LOD score for existence of this blood pressure QTL based on the combined populations (n = 330) was 5.66 and accounted for 9.2% of the total variance and 26% of the genetic variance.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Base Sequence
  • Blood Pressure*
  • Calcium-Calmodulin-Dependent Protein Kinases / genetics
  • Chromosome Mapping*
  • Female
  • Male
  • Molecular Sequence Data
  • Rats / genetics*
  • Rats, Inbred WKY
  • Sodium-Potassium-Exchanging ATPase / genetics

Substances

  • Calcium-Calmodulin-Dependent Protein Kinases
  • Sodium-Potassium-Exchanging ATPase

Associated data

  • GENBANK/U01223
  • GENBANK/U01224
  • GENBANK/U01225
  • GENBANK/U01226