Deletion polymorphism in the gene for angiotensin converting enzyme is associated with elevated fasting blood glucose levels

A Zingone; A Dominijanni; E Mele; O Marasco; F Melina; P Minchella; B Quaresima; M T Tiano; A Gnasso; A Pujia

doi:10.1007/BF00202873

Deletion polymorphism in the gene for angiotensin converting enzyme is associated with elevated fasting blood glucose levels

Hum Genet. 1994 Aug;94(2):207-9. doi: 10.1007/BF00202873.

Authors

A Zingone¹, A Dominijanni, E Mele, O Marasco, F Melina, P Minchella, B Quaresima, M T Tiano, A Gnasso, A Pujia, et al.

Affiliation

¹ Dipartimento di Medicina Sperimentale e Clinica, Università degli Studi di Reggio Calabria, Catanzaro, Italy.

PMID: 8045571
DOI: 10.1007/BF00202873

Abstract

The frequency and distribution of angiotensin converting enzyme insertion/deletion (ACE I/D) polymorphism, and its association with other known risk factors for coronary atherosclerosis, has been studied, in a normal south Italian population. Subjects homozygous for deletion showed elevated fasting blood glucose levels when compared with subjects homozygous for insertion. The difference was consistent with an increased number of type 2 diabetics among the former group of subjects.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Blood Glucose / genetics*
Coronary Artery Disease / genetics
Gene Deletion*
Genotype
Humans
Male
Middle Aged
Peptidyl-Dipeptidase A / genetics*
Polymorphism, Genetic / genetics*
Risk Factors

Substances

Blood Glucose
Peptidyl-Dipeptidase A