Abstract
We report the results observed in a large randomized study comparing radiotherapy alone to combined radiotherapy and chemotherapy in unresectable squamous cell and large cell lung carcinoma. Radiation dose was 65 Gy in both groups and chemotherapy included vindesine, cyclophosphamide, cisplatin and lomustine. One hundred seventy-seven patients received radiotherapy alone, and 176 received the combined treatment. The 2-year survival rate was 14% for patients receiving radiotherapy vs. 21% for patients receiving the combined treatment (P = 0.02). The distant metastasis rate was significantly lower in the group receiving the combined treatment (P < 0.001). Local control at 1 year was poor in both groups (17% and 15%, respectively) and remains a major problem in locally advanced non-small cell lung cancer.
Publication types
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Clinical Trial
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Clinical Trial, Phase III
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Comparative Study
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Multicenter Study
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Randomized Controlled Trial
MeSH terms
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Carcinoma, Large Cell / drug therapy
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Carcinoma, Large Cell / mortality
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Carcinoma, Large Cell / radiotherapy
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Carcinoma, Non-Small-Cell Lung / drug therapy
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Carcinoma, Non-Small-Cell Lung / mortality
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Carcinoma, Non-Small-Cell Lung / radiotherapy*
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Carcinoma, Squamous Cell / drug therapy
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Carcinoma, Squamous Cell / mortality
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Carcinoma, Squamous Cell / radiotherapy
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Cisplatin / administration & dosage
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Combined Modality Therapy
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Cyclophosphamide / administration & dosage
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Humans
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Life Tables
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Lomustine / administration & dosage
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Lung Neoplasms / drug therapy
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Lung Neoplasms / mortality
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Lung Neoplasms / radiotherapy*
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Neoplasm Recurrence, Local
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Survival Analysis
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Treatment Outcome
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Vindesine / administration & dosage
Substances
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Lomustine
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Cyclophosphamide
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Cisplatin
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Vindesine