Abstract
Blood lymphocytes from patients with eosinophilia are known to produce interleukin-5 (IL-5) with appropriate stimulation in vitro. To determine whether blood lymphocytes from these patients produce IL-5 in vivo, we tested the IL-5 mRNA expression in blood lymphocytes immediately after separation by reverse-transcriptase polymerase chain reaction (RT-PCR) method. We found that lymphocytes from eosinophilic patients expressed IL-5 mRNA, but lymphocytes from normal volunteers did not express the lymphokine. These findings suggest that in patients with eosinophilia, peripheral blood lymphocytes produce IL-5 in vivo.
MeSH terms
-
Adult
-
Angiolymphoid Hyperplasia with Eosinophilia / blood*
-
Angiolymphoid Hyperplasia with Eosinophilia / complications*
-
Angiolymphoid Hyperplasia with Eosinophilia / genetics
-
Animals
-
Antibodies, Helminth / blood
-
Base Sequence
-
Cells, Cultured
-
Child
-
Culture Media, Conditioned / pharmacology
-
Enzyme-Linked Immunosorbent Assay
-
Humans
-
Interleukin-5 / genetics*
-
Interleukin-5 / metabolism
-
Interleukin-5 / physiology
-
Lymphocytes / chemistry*
-
Lymphocytes / metabolism
-
Lymphocytes / pathology
-
Male
-
Middle Aged
-
Molecular Sequence Data
-
Paragonimiasis / blood*
-
Paragonimiasis / complications*
-
Paragonimiasis / immunology
-
Paragonimus / immunology
-
Polymerase Chain Reaction / methods
-
RNA, Messenger / analysis*
-
RNA, Messenger / genetics
Substances
-
Antibodies, Helminth
-
Culture Media, Conditioned
-
Interleukin-5
-
RNA, Messenger