Elevated frequency of an ETS-1 restriction fragment polymorphism in chronic B-cell leukaemia

P E Crossen; M J Morrison

doi:10.1007/BF00217361

Elevated frequency of an ETS-1 restriction fragment polymorphism in chronic B-cell leukaemia

Hum Genet. 1993 May;91(4):380-2. doi: 10.1007/BF00217361.

Authors

P E Crossen¹, M J Morrison

Affiliation

¹ Cytogenetic and Molecular Oncology Unit, Christchurch Hospital, New Zealand.

PMID: 8099060
DOI: 10.1007/BF00217361

Abstract

We studied the frequency of an SstI polymorphism in 70 patients with chronic B-cell leukaemia (CLL) and 100 normal controls. There was a highly significant difference in the distribution of the three genotypes between the CLL patients and the normal controls (chi 2 = 13.46, 2 df, P < 0.001). The C2 allele was found more frequently in CLL patients and may be a marker for a predisposition to develop CLL.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Aged, 80 and over
Alleles*
Chi-Square Distribution
Deoxyribonucleases, Type II Site-Specific
Female
Gene Frequency*
Genotype
Humans
Leukemia, Lymphocytic, Chronic, B-Cell / genetics*
Male
Middle Aged
Polymorphism, Restriction Fragment Length*
Proto-Oncogenes / genetics*

Substances

endodeoxyribonuclease SacI
Deoxyribonucleases, Type II Site-Specific