Abstract
Alzheimer disease and the prion disorders/spongiform encephalopathies share many common features. These chronic, progressive, sometimes familial diseases of the central nervous system are characterized by the presence of different types of amyloid deposits in the brain. This review provides a perspective on these two types of neurodegenerative disorders.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Alzheimer Disease* / genetics
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Alzheimer Disease* / metabolism
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Alzheimer Disease* / pathology
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Amyloid beta-Peptides / metabolism*
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Amyloidosis / pathology*
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Humans
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PrPSc Proteins
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Prion Diseases* / genetics
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Prion Diseases* / metabolism
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Prion Diseases* / pathology
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Prions / metabolism*
Substances
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Amyloid beta-Peptides
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PrPSc Proteins
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Prions