Abstract
The cause of Paget's disease is still unknown, despite many years of intensive study. During this time, evidence has sporadically emerged to suggest that the disease may result from a slow viral infection by one or more of the Paramyxoviruses. More recently, epidemiologic and molecular studies have suggested that the canine paramyxovirus, canine distemper virus, is the virus responsible for the disease. If true, then along with rabies, this would be a further example of a canine virus causing human disease. Studies in the natural host have now supported these findings. Further investigations have proposed that the bony abnormalities seen in Paget's disease are due to the effects of the virus on osteoclastic interleukin-6 and c-FOS production, possibly via the transcription factor NF-kappa B.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antibodies, Viral / blood
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Bone Diseases / microbiology
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Bone Diseases / veterinary
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Distemper / microbiology*
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Distemper Virus, Canine / genetics
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Distemper Virus, Canine / immunology
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Distemper Virus, Canine / isolation & purification
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Distemper Virus, Canine / pathogenicity*
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Dog Diseases / microbiology
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Dogs
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Genes, Viral
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Genetic Predisposition to Disease
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HLA Antigens / analysis
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Humans
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Interleukin-6 / biosynthesis
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NF-kappa B / physiology
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Osteitis Deformans / epidemiology
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Osteitis Deformans / genetics
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Osteitis Deformans / immunology
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Osteitis Deformans / microbiology*
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Osteoclasts / metabolism
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Osteoclasts / microbiology
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Proto-Oncogene Proteins c-fos / biosynthesis
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Reactive Oxygen Species
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Species Specificity
Substances
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Antibodies, Viral
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HLA Antigens
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Interleukin-6
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NF-kappa B
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Proto-Oncogene Proteins c-fos
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Reactive Oxygen Species